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L'X fragile sera vaincu | Fragile X will be conquered

Archive for Alzheimer

Mouse model hints at Alzheimer’s therapies for fragile X

Sfari.org |

Lowering the levels of proteins associated with Alzheimer’s disease can improve symptoms of fragile X syndrome in mice, according to a poster presented Wednesday at the Society for Neuroscience annual meeting.

Fragile X syndrome is the most common inherited cause of cognitive disability, and the most common known cause of autism. It is caused by a mutation in the FMR1 gene, which encodes FMRP, a regulatory protein.

One of FMRP’s targets is amyloid precursor protein or APP. In turn, APP can be processed by the body to form beta-amyloid, the molecule that forms plaques in the brains of people with Alzheimer’s disease.

“Our previous work has shown that amyloid precursor protein and beta-amyloid are increased in FMR1 knockout mice,” says study leader Cara Westmark, associate scientist in pathology and laboratory medicine at the University of Wisconsin.

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