080210xf's Blog

L'X fragile sera vaincu | Fragile X will be conquered

Mark Bear: Charting New Waters

Entrevue avec Mark Bear, auteur de la théorie des mGluR, théorie en amont des études cliniques en cours dans le syndrome du X fragile (avec les antagonistes mGluR5 et l’arbaclofen), théorie annonciatrice, aussi – espérons-le – d’un changement de paradigme dans le traitement de la déficience intellectuelle d’origine génétique.

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By Madeline Drexler, hhmi.org |

(…)

Mark Bear—a champion helmsman and neuroscientist at the Massachusetts Institute of Technology—says he applies the same principles to racing and research.

“You begin with probabilities. You don’t know a priori whether heading off to the left side of the racecourse or the right is the way to go. So you collect information, make observations, test hypotheses. You do a few pilot experiments, sailing upwind a little in either direction, to see what looks promising. You make a plan, and take measurements of whether or not the plan is working. If you made a wrong guess, you make on-course corrections.

“But what really separates great sailors from less great sailors,” adds the HHMI investigator, “is that they see things that other people don’t.”

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