080210xf's Blog

L'X fragile sera vaincu | Fragile X will be conquered

Clear Neuroanatomical Differences Between Autism, Fragile X – Similarities End With Behavior

Deborah Brauser, Medscape |

March 31, 2011 — Distinct neuroanatomical patterns exist between fragile X syndrome (FXS) and autism of unknown cause, even though both disorders appear to share overlapping behaviors, a new imaging study suggests.

In a comparison study of 165 male toddlers, investigators found that compared with healthy controls, those diagnosed as having FXS or idiopathic autism (iAUT) had significant differences in the frontal and temporal gray and white matter regions often associated with social cognition.

However, the iAUT group had greater volume levels in these regions than controls, and the FXS group had lower volume levels.

“To better treat children who have these autistic syndromes, it’s important to identify the neurodevelopmental pathways that go awry. It then gives us a template to understand not only how things have gone wrong, but it can potentially tell us how to make it right,” coinvestigator Allan L. Reiss, MD, director of the Center for Interdisciplinary Brain Sciences Research and professor of psychiatry at Stanford University School of Medicine, California, told Medscape Medical News.

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