080210xf's Blog

L'X fragile sera vaincu | Fragile X will be conquered

Genetic background alters behavior of fragile X mice

Deborah Rudacille, Sfari.org |

Six strains of mice lacking a gene associated with fragile X syndrome show radically different behaviors though they share the same mutation, researchers reported in January in Autism Research1.


Fragile X syndrome is caused by the complete or partial loss of FMR protein, which results from a full or partial mutation of theFMR1 gene. People with the syndrome combine varying degrees of intellectual disability with seizures, irritability, hyperactivity, anxiety or self-injurious behavior. Up to one-half of people with fragile X syndrome also meet diagnostic criteria for autism.

Researchers suspect that the wide range of fragile X symptoms is the result of differences in genetic, environmental and perhaps epigenetic factors — which affect gene expression without altering DNA2.


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