080210xf's Blog

L'X fragile sera vaincu | Fragile X will be conquered

Antibiotic proves promising as fragile X treatment

Sfari.org |

Minocycline, an antibiotic approved to treat various infections including acne, can increase vocalizations and provide long-lasting improvements in anxiety in a fragile X mouse model, according to two posters presented at the Society for Neuroscience annual meeting in San Diego.

Minocycline is a new treatment for fragile X syndrome that showed promising results in a preliminary uncontrolled human study. It is undergoing more rigorous clinical testing at the University of California Davis MIND institute.

In one of the new studies, the researchers gave minocycline for four weeks after birth to mice lacking the fragile X mental retardation protein, or FMRP. The treatment eases symptoms of hyperactivity and anxiety in these mice, and the effect lasts for at least four weeks after stopping treatment.

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