080210xf's Blog

L'X fragile sera vaincu | Fragile X will be conquered

Molecular mechanisms: Fragile X mutation worsens memory loss

Jessica Wright, Sfari.org |

Genes responsible for Alzheimer’s disease and fragile X syndrome — a form of mental retardation linked to autism — may operate through the same pathway, according to a study published in July in The Journal of Neuroscience.

Fruit flies with a mutation in presenilin, a gene linked to inherited Alzheimer’s disease, show long- and short-term memory loss at an earlier age than do controls, the study shows. This effect is even more dramatic — cutting the fly’s age from 30 to 5 days — when the mutation is combined with a second one in the fly fragile X gene, dFMR1.

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