080210xf's Blog

L'X fragile sera vaincu | Fragile X will be conquered

Next Decade Of Brain Research Promises New Answers

In the decade since the first draft sequence of the human genome was released, a new field – neurogenetics – has taken wing, said leaders in the field from Baylor College of Medicine and Emory University School of Medicine in Atlanta in an overview published in the journal Neuron.

It was already building toward such success. In the 1990s, using the tools available at the time, scientists had already found critical genes such as that for Duchenne muscular dystrophy, Charcot-Marie Tooth and fragile X, said Dr. Huda Y. Zoghbi, professor of molecular and human genetics, pediatrics, neuroscience and neurology at BCM, and Dr. Stephen T. Warren, professor of human genetics, pediatrics and biochemistry at Emory. Zoghbi is also director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital and a Howard Hughes Medical Institute investigator.
Mapping and sequencing

Zoghbi and her colleagues at BCM cloned the gene for Rett syndrome in 1999, a success made possible by the intense mapping and sequencing efforts of the X chromosome that preceded it. In their essay, Zoghbi and Warren note that national investment in such research has already paid off, not only in diagnosis and understanding of such diseases but also in the outlook for families afflicted by the disorders.


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