080210xf's Blog

L'X fragile sera vaincu | Fragile X will be conquered

SAGE Labs teams on preclinical Autism model development, By Gareth Macdonald, 28-Oct-2010 |

Related topics: Preclinical Research, Preclinical

SAGE Labs will create rodent autism models for preclinical drug discovery and development in collaboration with advocacy group Autism Speaks.

The firm, part of Sigma Aldrich, will use its CompoZr zinc finger nuclease (ZFN) platform to create knockout rat strains representing various symptoms of autism and related disorders like Fragile X and Rett syndrome.

Unit director Edward Weinstien told Outsourcing-pharma the firm anticipates a strong response from the preclinical research sector when the new strains become commercially available next year.

“While there are many mouse models available for Autism research, I believe the overwhelming consensus is that the mouse is a suboptimal model for this condition.

“Our conversations with the research community, greatly facilitated by the members of Autism Speaks, make us believe that genetically engineered rats will be extremely valuable.”


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