080210xf's Blog

L'X fragile sera vaincu | Fragile X will be conquered

Tackling cognitive deficits in Alzheimer’s disease: 1 ‘STEP’ at a time

La recherche dans le domaine de l’Alzheimer et du X fragile se recoupent. En voici une autre démonstration :

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. . . In addition to Alzheimer’s disease, increased levels of STEP in the brain have been implicated in other disorders such as schizophrenia and Fragile X, which is characterized by cognitive deficits and other disabilities. Once again, high levels of STEP proteins remove glutamate receptors from synapses and contribute to the cognitive deficits present in these diseases.

“These new findings need to be replicated, but if genetically reducing STEP levels is improving cognition, we could perhaps discover a drug designed to reduce STEP activity,” said Lombroso. “Our current work is focused on looking for STEP inhibitors.”

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